Lithium Hydroxide → (2S)-2-{[(Benzyloxy)carbonyl]amino}-4,4-difluorobutanoic acid

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Reaction Steps

To a solution of 250 mg (S)-2-Benzyloxycarbonylamino-4,4-difluoro-butyric acid methyl ester in 2 ml THF was added a solution of 21 mg LiOH in 0.5 ml water at 0° C. After 2 h the mixture was brought to pH 4 by using Amberlite IR-120 ion exchange resin. The reaction mixture was filtered and concentrated and the crude product obtained used in the next step without further purification. Yield: 229 mg

Provenance & Evidence