HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → HCID 68599828, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | Butyl piperazine-1-carboxylate | HCID 21963126 | — |
| Reactant | (2S)-2-{[(Benzyloxy)carbonyl]amino}-4,4-difluorobutanoic acid | HCID 58715226 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68599828 | HCID 68599828 | — |
Reaction Steps
To a solution of 114 mg (S)-2-Benzyloxycarbonylamino-4,4-difluoro-butyric acid were added 0.11 ml N-ethylmorpholine, 138 mg TOTU and 78 mg 1-butoxycarbonylpiperazine. After stirring for 12 h the reaction mixture was diluted with ethyl acetate and washed with aqueous LiCl (4%), 0.1 M HCl, saturated aqueous NaHCO3 and brine. The crude product obtained was used without further purification. Yield: 150 mg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669266B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-f7996bce06054564b4b36c6cbfc0d070 |
| Source note | uspto-grants-2014_03 |