HCID 68600671, compound → HCID 54773405, compound

HRID 1185545Notes

Reaction equation

HRID 1185545 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:26])[CH2:13][N:14](C(OCC2C=CC=CC=2)=O)[CH3:15])[CH2:8][CH2:7]1)=[O:5])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:26])[CH2:13][NH:14][CH3:15])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 68600671HCID 68600671, compound

Product 1

HCID 54773405HCID 54773405, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 830 mg 4-[2-(Benzyloxycarbonyl-methyl-amino)-acetyl]-piperazine-1-carboxylic acid ethyl ester in 30 ml ethanol were added 100 mg Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (3 bar) for 12 h. The reaction mixture was filtrated over a plug of Celite®, washed with ethanol and concentrated. Yield: 490 mg colorless oil.

Workup

  1. filtrationThe reaction mixture was filtrated over a plug of Celite®
  2. washwashed with ethanol
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-86a3113f1bdf4b8581a7eeb35744ca5c
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

Loading…