HCID 66855424, compound → 1-Cyclobutoxycarbonylpiperazine

Participants

Reaction Steps

A suspension of 5.90 g Piperazine-1,4-dicarboxylic acid benzyl ester cyclobutyl ester and 0.25 g Pd/C (10%) in 50 ml ethyl acetate was stirred under an atmosphere of hydrogen (3 bar) for 12 h. The mixture was filtrated over a plug of Celite, washed with ethyl acetate and the combined wash solutions concentrated to give the title compound as colourless oil. Yield: 3.3 g.

Provenance & Evidence