HCID 68600587, compound → HCID 68598860, compound

HRID 1185552Notes

Reaction equation

HRID 1185552 reaction equation
[F:1][C:2]([F:25])([F:24])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10][CH2:9]1)=[O:7]>C(O)C.[Pd]>[F:25][C:2]([F:1])([F:24])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)=[O:7]

Participants

4

Reactant 1

HCID 68600587HCID 68600587, compound

Product 1

HCID 68598860HCID 68598860, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 3.2 g Piperazine-1,4-dicarboxylic acid benzyl ester 3,3,3-trifluoro-propyl ester in 60 ml ethanol were added 200 mg Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (3 bar) for 12 h. The reaction mixture was filtrated over a plug of Celite®, washed with ethanol and concentrated. Yield: 2.0 g colorless oil.

Workup

  1. filtrationThe reaction mixture was filtrated over a plug of Celite®
  2. washwashed with ethanol
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f95c889d7d014d4e841bc339f69c3f59
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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