HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → HCID 68600578, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | HCID 68598860 | HCID 68598860 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68600578 | HCID 68600578 | — |
Reaction Steps
To a solution of 842 mg N-Benzyloxycarbonyl glycine were added 2.0 ml N-ethylmorpholine, 1.32 g TOTU and 910 mg Piperazine-1-carboxylic acid 3,3,3-trifluoro-propyl ester. After stirring for 48 h the reaction mixture was diluted with ethyl acetate and washed with aqueous LiCl (4%), 0.1 M HCl, saturated aqueous NaHCO3 and brine. The crude product obtained was used without further purification. Yield: 1.63 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669266B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-482506856de8461488dbed60456e1883 |
| Source note | uspto-grants-2014_03 |