Cesium carbonate → HCID 68599959, compound

Participants

Reaction Steps

To a solution of 1.1 g 6-Chloro-4-hydroxy-7-methyl-quinoline-2-carboxylic acid ethyl ester in 25 ml DMF were added 2.7 g of cesium carbonate followed by dropwise addition of a solution of 1.8 g (S)-1-(2-Bromo-acetyl)-pyrrolidine-2-carboxylic acid cyclobutylamide in 25 ml DMF over a period of 3 h. After this time another portion of cesium carbonate (700 mg) and (S)-1-(2-Bromo-acetyl)-pyrrolidine-2-carboxylic acid cyclobutylamide (700 mg) were added over 1.5 h. The mixture was evaporated, diluted with DCM and washed with aqueous LiCl (4%). The crude product obtained after evaporation of the solvent was pure enough for the subsequent transformation. Yield: 3.3 g.

Provenance & Evidence