Sodium Hydroxide → HCID 68601682, compound

Participants

Reaction Steps

To a solution of 3.2 g 6-Chloro-4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carboxylic acid ethyl ester in 20 ml THF were added 6.7 ml aqueous NaOH (1 M) at 0° C. After 4 h the mixture was brought to pH 4 by using Amberlite IR-120 ion exchange resin. The reaction mixture was filtered and concentrated and the crude product obtained used in the next step without further purification. Yield: 2.78 g.

Provenance & Evidence