Hydrochloric Acid → 4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carboxylic acid

Participants

Reaction Steps

To a solution of 6.30 g 4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carboxylic acid methyl ester in 14 ml THF were added 14.3 ml aqueous NaOH (1 M) and the reaction mixture was stirred for 4 h at RT. The reaction mixture was acidified with 15 ml 1 M HCl, concentrated to a volume of 25 ml and extracted with DCM to give the crude product after evaporation of the solvent. Yield: 5.00 g

Provenance & Evidence