3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester → 6-[5-(6-Bromo-naphthalen-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

HRID 1185854Notes

Reaction equation

HRID 1185854 reaction equation
C(OC(N1C([C:14]2[NH:15][C:16]([C:19]3[CH:24]=[CH:23][C:22](Br)=[CH:21][CH:20]=3)=[CH:17][N:18]=2)C2CC1CC2)=O)(C)(C)C.[CH2:27]([O:34][C:35]([N:37]1[CH2:43][CH2:42][C:39]2([CH2:41][CH2:40]2)[CH2:38]1)=[O:36])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C(OC(N1C(C(=O)NCC(C2C=[CH:66][C:65]([Br:68])=[CH:64][CH:63]=2)=O)C2CC1CC2)=O)(C)(C)C>>[CH2:27]([O:34][C:35]([N:37]1[CH:43]([C:14]2[NH:15][C:16]([C:19]3[CH:20]=[CH:21][C:22]4[C:23](=[CH:63][CH:64]=[C:65]([Br:68])[CH:66]=4)[CH:24]=3)=[CH:17][N:18]=2)[CH2:42][C:39]2([CH2:41][CH2:40]2)[CH2:38]1)=[O:36])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 3

HCID 596106863-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl esterHCID 596109073-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl esterHCID 68030140HCID 68030140, compound

Product 1

HCID 666205806-[5-(6-Bromo-naphthalen-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

Procedure

Title compound was prepared according to the method employed to prepare 3-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (Example AS), substituting 642-(6-Bromo-naphthalen-2-yl)-2-oxo-ethylcarbamoyl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester for 3-[2-(4-bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-1cd3dd599f9c474c9ff92c0de7a3e957
Source dataset
uspto-grants-2014_03
Patent number
US08669234B2

Reaction notes

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