Methanol → Methyl 2-(2,4-dinitrophenyl)acetate

HRID 1185966ノート

反応式

HRID 1185966 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[CH2:13][C:14]([OH:16])=[O:15])([O-:3])=[O:2].CO.[CH3:19][Si](C=[N+]=[N-])(C)C>C1(C)C=CC=CC=1>[CH3:19][O:15][C:14](=[O:16])[CH2:13][C:5]1[CH:6]=[CH:7][C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

参加物

5

反応物 3

HCID 887MethanolHCID 167693TrimethylsilyldiazomethaneHCID 2215132,4-Dinitrophenylacetic acid2 回

生成物 1

HCID 286146Methyl 2-(2,4-dinitrophenyl)acetate収率 95%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 250 ml three-necked conical flask equipped with a nitrogen inlet and a stirrer was purged with nitrogen, and was added with 2,4-dinitrophenylacetic acid (2.26 g, 0.01 mole), methanol (20 ml) and toluene (83 ml). Stirring was conducted at room temperature until 2,4-dinitrophenylacetic acid was dissolved. Trimethylsilyldiazomethane (8.3 ml) was then added, and reaction was conducted for 3 hours at room temperature. Solvent was removed by distilling under a reduced pressure and by drying at 70° C. to obtain 2,4-dinitrophenylacetic acid methyl ester (2.28 g, yield: 95%).

後処理

  1. customA 250 ml three-necked conical flask equipped with a nitrogen inlet and a stirrer
  2. customwas purged with nitrogen
  3. dissolutionwas dissolved
  4. customreaction
  5. customSolvent was removed
  6. distillationby distilling under a reduced pressure
  7. customby drying at 70° C.

出典と根拠

ORDレコード
ord-db3684c7d62a4922b2c71ffc12222c9c
出典データセット
uspto-grants-2014_03
特許番号
US08673177B2

反応ノート

読み込み中…