反应详情

A 250 ml three-necked conical flask equipped with a nitrogen inlet and a stirrer was purged with nitrogen, and was added with 2,4-dinitrophenylacetic acid (2.26 g, 0.01 mole), methanol (20 ml) and toluene (83 ml). Stirring was conducted at room temperature until 2,4-dinitrophenylacetic acid was dissolved. Trimethylsilyldiazomethane (8.3 ml) was then added, and reaction was conducted for 3 hours at room temperature. Solvent was removed by distilling under a reduced pressure and by drying at 70° C. to obtain 2,4-dinitrophenylacetic acid methyl ester (2.28 g, yield: 95%).

1. customA 250 ml three-necked conical flask equipped with a nitrogen inlet and a stirrer
2. customwas purged with nitrogen
3. dissolutionwas dissolved
4. customreaction
5. customSolvent was removed
6. distillationby distilling under a reduced pressure
7. customby drying at 70° C.