2-Bromo-4'-methylacetophenone → Methyl 2-(4-methylphenyl)imidazo[1,2-a]pyridine-6-carboxylate

Participants

Reaction Steps

2-Bromo-4′-methylacetophenone 2 (14.5 g, 65.1 mmol) was added to a hot solution of methyl 2-aminopyridine-5-carboxylate 1 (9.0 g, 61.1 mmol) in ethanol (280 ml). The solution was then heated at reflux for 6 h, cooled to room temperature and the white solid filtered and washed with ethanol to give methyl 2-(4-tolyl)-imidazo[1,2-a]pyridine-6-carboxylate 3 (13.9 g, 80%).

Provenance & Evidence