Ammonia → HCID 131731244, compound

HRID 1186004Notes

Reaction equation

HRID 1186004 reaction equation
[NH3:1].C([O:5][CH2:6][C@@H:7]([NH:33][C:34]([O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:35])[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C@H:11]1[C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22]([NH:24][C@@H:25]([C@H:30]([OH:32])[CH3:31])[C:26]([O:28]C)=[O:27])=[O:23])=[O:16])=[O:9])(=O)C>>[CH2:37]([O:36][C:34](=[O:35])[NH:33][C@H:7]([CH2:6][OH:5])[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C@H:11]1[C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:23])[NH:24][C@@H:25]([C@H:30]([OH:32])[CH3:31])[C:26]([O:28][NH2:1])=[O:27])=[O:16])=[O:9])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 71245379HCID 71245379, compound

Product 1

HCID 131731244HCID 131731244, compoundYield 82.3%

Procedure

A solution of methanolic ammonia (3 mL) was added to compound 5 (0.28 g, 0.47 mmol) and stirred at RT for 18 h. The volatiles were evaporated under reduced pressure to afford compound 6 (0.21 g, 82.3%).

Workup

  1. customThe volatiles were evaporated under reduced pressure

Sources & evidence

ORD record
ord-b59d7af52e4749c88d23d778e77ac057
Source dataset
uspto-grants-2014_03
Patent number
US08673843B2

Reaction notes

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