Potassium Hydroxide → HCID 15282610, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of compound 2 (8.0 g, 21.79 mmol) in CH3OH (20 mL) was added 2N aqueous KOH (20 mL) and heated up to 100° C. and stirred for 16 h. The volatiles were evaporated under reduced pressure. The residue obtained was diluted with ice cold water (50 mL) and washed with ether (50 mL). The aqueous layer was acidified to pH˜2 using HCl solution and extracted with EtOAc (2×100 mL). The combined organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford compound 3 (6 g, 81%) as an off white solid.

Provenance & Evidence