HCID 71245377, compound → HCID 71245465, compound

HRID 1186018Notes

Reaction equation

HRID 1186018 reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C:12]1([C:23](=[O:36])[NH:24][C@@H:25]([C@H:30]([O:32][C:33](=[O:35])[CH3:34])[CH3:31])[C:26]([O:28][CH3:29])=[O:27])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[C:33]([O:32][C@H:30]([CH3:31])[C@H:25]([NH:24][C:23]([C:12]1([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:13][CH2:14][CH2:15][NH:11]1)=[O:36])[C:26]([O:28][CH3:29])=[O:27])(=[O:35])[CH3:34]

Participants

4

Reactant 1

HCID 71245377HCID 71245377, compound

Product 1

HCID 71245465HCID 71245465, compoundYield 75.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a stirring solution of compound 5 (4 g, 8.06 mmol) in ethanol (50 mL) was added 10% Pd/C (1.2 g) and the reaction mixture was stirred under H2 atmosphere (balloon pressure) for 4 h. It was filtered through celite pad and the filtrate was concentrated under reduced pressure to yield compound 6 (2.2 g, 75%).

Workup

  1. filtrationIt was filtered through celite pad
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-928f0083632843818c14f7b6deed87ac
Source dataset
uspto-grants-2014_03
Patent number
US08673843B2

Reaction notes

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