HCID 67060801, compound → HCID 70664257, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-N-(3-((tert-butyldimethylsilyl)oxy)propyl)-2-nitroaniline from above was added to 2:1 2-propanaol:water (75 mL) (precipitate formed). Iron powder was added (1.147 g, 20.6 mmol) and the mixture was heated to 80° C. for 1 h. It turned black. After allowing to cool, the mixture was filtered through celite, rinsing with ethyl acetate. The filtrate was washed with water, washed with then brine, dried (MgSO4), filtered, and concentrated to give crude 5-bromo-N1-(3-((tert-butyldimethylsilyl)oxy)propyl)benzene-1,2-diamine.

Provenance & Evidence