3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid → HCID 86660413, compound

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Reaction Steps

The compound was prepared in an analogous manner as described for intermediate B14A from (S)-5-(5-amino-2-fluoro-phenyl)-5,7,7-trimethyl-[1,4]oxazepane-3-thione (intermediate A17A) (106 mg, 0.38 mmol) and commercially available 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid [CAS No. 80194-68-9] (100 mg, 0.44 mmol). The compound was obtained as light yellow foam (133 mg, 61%). MS (ISP): m/z=490.2 [(M+H)+] and 492.3 [(M+2+H)+].

Provenance & Evidence