(3-Bromophenyl)acetyl chloride → (3-Bromo-phenyl)-acetic acid allyl ester

HRID 1186162Notes

Reaction equation

HRID 1186162 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9](Cl)=[O:10])[CH:5]=[CH:6][CH:7]=1>CCCCCCC.C(OCC)(=O)C>[CH2:9]([O:10][C:9](=[O:10])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH:8]=[CH2:4]

Participants

3

Reactant 1

HCID 13486899(3-Bromophenyl)acetyl chloride

Product 1

HCID 58563080(3-Bromo-phenyl)-acetic acid allyl ester

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in an analogous manner as described for intermediate B3A from (3-bromo-phenyl)-acetyl chloride (intermediate B2B) (12.1 g, ca. 50 mmol). The compound was obtained after silica gel column chromatography with n-heptane/ethyl acetate as a light yellow liquid (7.934 g, 62%). MS (ISP): m/z=272.1 [(M+NH4)+] and 274.1 [(M+2+NH4)+]

Sources & evidence

ORD record
ord-358179c558304de88e1d9ae152556a53
Source dataset
uspto-grants-2014_03
Patent number
US08673894B2

Reaction notes

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