Lithium hydroxide, monohydrate → HCID 76831113, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (1SR,6RS)-1-(5-bromo-2-fluoro-phenyl)-4-oxa-2-aza-bicyclo[4.1.0]heptan-3-one (intermediate B7A) (1.48 g, 5.17 mmol) and lithium hydroxide monohydrate (LiOH.H2O) (2.17 g, 52 mmol) in ethanol (EtOH) (2.5 ml) and water (12.5 ml) was stirred at 100° C. for 16 h. Poured into ice water, added brine, extracted twice with tert-butyl methyl ether (TBME), washed organic layer with brine, dried over sodium sulfate. Removal of the solvent in vacuum left the title compound as a light brown oil (1.224 g, 91%), which was used without further purification. MS (ISP): m/z=242.2 [(M−NH2)+] and 244.2 [(M+2−NH2)+].

Provenance & Evidence