Lawesson's reagent → HCID 76831279, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (1SR,7RS)-1-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-oxa-2-aza-bicyclo[5.1.0]octan-3-one (intermediate B11A) (460 mg, 1.15 mmol) in dioxane (3 ml) at 23° C. was added 2,4-bis-(4-methoxy-phenyl)-[1,3,2,4]dithiadiphosphetane 2,4-disulfide (Lawesson's reagent) (292 mg, 0.72 mmol) and the mixture was stirred at 80° C. for 2 h. The green solution was poured on sat. NaHCO3 solution, extracted with ethyl acetate, washed the organic layer with brine and dried over sodium sulfate. Removal of the solvent in vacuum left the title compound as a green oil (600 mg, ca. 80% pure, 100%), which was used in the next step without further purification. MS (ISP): m/z=417.3 [(M+H)+].

Provenance & Evidence