5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid → HCID 86660420, compound

Participants

Reaction Steps

Prepared in an analogous manner as described for intermediate B14A from (1SR,7RS)-1-(5-amino-2-fluoro-phenyl)-5-oxa-2-aza-bicyclo[5.1.0]octane-3-thione (intermediate B13A) (87 mg, 0.34 mmol) and 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [CAS-no 881409-53-6; described in example 49] (80 mg, 0.36 mmol). The title compound was obtained as a light yellow solid (143 mg, 87%). MS (ISP): m/z=456.1 [(M+H)+].

Provenance & Evidence