5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid → HCID 86660422, compound

Participants

Reaction Steps

The compound was prepared in an analogous manner as described for intermediate B14A from (1SR,7RS)-1-(3-amino-phenyl)-5-oxa-2-aza-bicyclo[5.1.0]octane-3-thione (intermediate B13B) (166 mg, 0.712 mmol) and 5-(2,2,2-trifluoro-ethoxy) -pyridine-2-carboxylic acid [CAS No. 881409-53-6; described in example 49] (150 mg, 0.68 mmol). The title compound was obtained as a light yellow gum (266 mg, 90%). MS (ISP): m/z=438.1 [(M+H)+].

Provenance & Evidence