HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid → 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid | HCID 2821908 | — |
| Reactant | (R)-3-(5-amino-2-fluoro-phenyl)-3-methyl-[1,4]oxazepan-5-one hydrochloride | HCID 67468567 | — |
| Product | 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)-phenyl]-amide | HCID 67463301 | — |
Reaction Steps
Starting from 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid and (R) -3-(5-amino-2-fluoro-phenyl)-3-methyl-[1,4]oxazepan-5-one hydrochloride, the 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)-phenyl]-amide was obtained as a light yellow foam. MS (ISP): m/z=446.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673894B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-55f269221e424db58ed3e6dc8878d492 |
| Source note | uspto-grants-2014_03 |