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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1186189Generated: November 1, 2026

5-Cyanopyridine-2-carboxylic acid → 5-cyano-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)-phenyl]-amide

https://huagongshe.com/reaction/1186189

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Cyanopyridine-2-carboxylic acidHCID 12400734—
Reactant(R)-3-(5-amino-2-fluoro-phenyl)-3-methyl-[1,4]oxazepan-5-one hydrochlorideHCID 67468567—
Product5-cyano-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)-phenyl]-amideHCID 67467044—

Reaction Steps

Starting from 5-cyano-pyridine-2-carboxylic acid and (R)-3-(5-amino-2-fluoro-phenyl)-3-methyl-[1,4]oxazepan-5-one hydrochloride, the 5-cyano-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)-phenyl]-amide was obtained as a white solid. MS (ISP): m/z=369.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673894B2
Source datasetuspto-grants-2014_03
ORD IDord-db1148357b264a8b84c88e8291ef0c6a
Source noteuspto-grants-2014_03