3-Chloro-5-cyanopyridine-2-carboxylic acid → (R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide formate

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Reaction Steps

The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) and 3-chloro-5-cyano-pyridine-2-carboxylic acid (prepared according to Hori, A. et al., Int. Patent Application Publ. No. WO2009151098) yielded the title compound as a pale yellow solid. MS (ISP): m/z=438.1 [M+H]+.

Provenance & Evidence