HCID 57827789, compound → HCID 54578016, compound

HRID 1186203Notes

Reaction equation

HRID 1186203 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C@:8]2([CH3:18])[C:14]([F:16])([F:15])[CH2:13][O:12][CH2:11][C:10]([NH2:17])=[N:9]2)[CH:7]=1.[F:20][CH2:21][CH2:22][O:23][C:24]1[N:25]=[CH:26][C:27]([C:30]([OH:32])=[O:31])=[N:28][CH:29]=1>>[CH:30]([OH:32])=[O:31].[NH2:17][C:10]1[CH2:11][O:12][CH2:13][C:14]([F:15])([F:16])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:30]([C:27]3[CH:26]=[N:25][C:24]([O:23][CH2:22][CH2:21][F:20])=[CH:29][N:28]=3)=[O:31])[CH:3]=[CH:4][C:5]=2[F:19])([CH3:18])[N:9]=1

Participants

3

Reactant 2

HCID 57827789HCID 57827789, compoundHCID 58562966(R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine

Product 1

HCID 54578016HCID 54578016, compound

Procedure

The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) and 5-(2-fluoro-ethoxy) -pyrazine-2-carboxylic acid (prepared according to Suzuki, Y. et al., Int. Patent Application Publ. No. WO2009091016) yielded the title compound as an off-white amorphous material. MS (ISP): m/z=442.3 [M+H]+.

Sources & evidence

ORD record
ord-4759de4fcb4d4278b8c0f0c793c8d0b9
Source dataset
uspto-grants-2014_03
Patent number
US08673894B2

Reaction notes

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