HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine → HCID 86660426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine | HCID 58562966 | — |
| Reactant | HCID 66456273 | HCID 66456273 | — |
| Product | HCID 86660426 | HCID 86660426 | — |
Reaction Steps
The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) and 6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid (prepared according to Suzuki, Y. et al., Int. Patent Application Publ. No. WO2009091016) yielded the title compound as an off-white solid. MS (ISP): m/z=478.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673894B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-89dae3bd392e4831bca05a0606a6e0c9 |
| Source note | uspto-grants-2014_03 |