HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Fluoromethoxy)pyrazine-2-carboxylic acid → (R)-N-(3-(3-Amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Fluoromethoxy)pyrazine-2-carboxylic acid | HCID 57475676 | — |
| Reactant | (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine | HCID 58562966 | — |
| Product | (R)-N-(3-(3-Amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide formate | HCID 54579133 | — |
Reaction Steps
The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) and 5-fluoromethoxy-pyrazine-2-carboxylic acid (prepared according to Suzuki, Y. et al., Int. Patent Application Publ. No. WO2009091016) yielded the title compound as a light brown solid. MS (ISP): m/z=428.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673894B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-4854f6f4642f4bd6a1bcc41023b5fecd |
| Source note | uspto-grants-2014_03 |