Water → HCID 68213456, compound

Participants

Reaction Steps

550 mg (1.29 mmol) of the compound from Example 3A were dissolved in 35 ml of DMF, 320 μl (1.6 mmol) of 4-tert-butylbenzyl bromide and 1.4 g (4.14 mmol) of cesium carbonate were added and the mixture was stirred at RT for 18 h. Water was then added, and the mixture was extracted repeatedly with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated. The crude product obtained was purified by preparative HPLC (method 1).

Provenance & Evidence