Hydrochloric Acid → HCID 54596157, compound

Participants

Reaction Conditions

Reaction Steps

68.5 mg (0.12 mmol) of the compound from Example 5A were dissolved in 0.5 ml of methanol and 1 ml of dioxane, 0.15 ml of 45% strength aqueous sodium hydroxide solution and 0.2 ml of water were added and the mixture was then stirred at a bath temperature of 100° C. for 45 min. The milky suspension was then diluted with water, acidified with 2 N hydrochloric acid and extracted repeatedly with dichloromethane. The combined organic phases were dried over sodium sulfate and concentrated. The residue was purified by preparative HPLC (method 1).

Provenance & Evidence