Trifluoroacetic acid → HCID 67401257, compound

Participants

Reaction Steps

4-(N-{3-[2,2,2-trifluoro-1-(pyridin-3-yl)ethoxy]quinoxalin-2-yl}sulfamoyl)phenethylcarbamate (Compound 208) was dissolved in dichloromethane (2 mL). To this, trifluoroacetic acid (2 mL) was added at room temperature and the mixture was stirred at room temperature for 24 hours. The solvent in the reaction mixture was evaporated off under reduced pressure, and purification by silica gel column chromatography (ethyl acetate/methanol=1/0 to 5/1) was performed to give 4-(2-aminoethyl)-N-{3-[2,2,2-trifluoro-1-(pyridin-3-yl)-ethoxy]quinoxalin-2-yl}benzenesulfonamide (Compound 209) (48 mg, 90%).

Provenance & Evidence