Hydrochloric Acid → HCID 86657926, compound

Participants

Reaction Steps

Compound 272 (72.0 mg, 0.136 mmol) obtained in Example 266 was dissolved in THF (1.50 mL). To this, a 1.00 mol/L aqueous hydrochloric acid solution (1.50 mL) was added and the mixture was stirred at room temperature for 1.5 hours. The reaction was stopped by addition of a saturated aqueous sodium bicarbonate solution to the reaction mixture, and extraction with ethyl acetate was performed, followed by washing with brine and drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/1) to give Compound 273 (41.6 mg, yield: 67%).

Provenance & Evidence