Ethanol → HCID 67402096, compound

Participants

Reaction Steps

Ten percent palladium/carbon (15.0 mg) was suspended in tetrahydrofuran (1.0 mL). To this, a tetrahydrofuran solution (2.0 mL) of N-{3-[2,2,2-trifluoro-1-(1-benzyloxycarbonylpiperidin-4-yl)ethoxy]quinoxalin-2-yl}propane-1-sulfonamide (150 mg, 0.245 mmol) was added and the mixture was stirred under hydrogen stream at room temperature for 3 days. To the reaction mixture, 10% palladium/carbon (15.0 mg) and ethanol (2.0 mL) were added and the mixture was stirred under hydrogen stream at room temperature for 8 hours. The reaction mixture was filtered through Celite and the solvent was evaporated off under reduced pressure. The residue was purified by preparative thin-layer chromatography (chloroform/methanol=9/1) to give Compound 327 (38.7 mg, yield: 37%).

Provenance & Evidence