Triethylamine → HCID 86657934, compound

Participants

Reaction Steps

2-Chloro-3-[2,2,2-trifluoro-1-(4-fluoropiperidin-4-yl)-ethoxy]quinoxaline hydrochloride (157 mg, 0.396 mmol) was dissolved in dichloromethane (3.0 mL). To this, triethylamine (0.197 mL, 1.19 mmol) and methanesulfonyl chloride (0.0459 mL, 0.594 mmol) were successively added and the mixture was stirred at room temperature for 1 hour. The reaction was stopped by addition of a saturated aqueous sodium bicarbonate solution to the reaction mixture, and extraction with dichloromethane was performed, followed by drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=7/3) to give Compound BAI (146 mg, yield: 84%).

Provenance & Evidence