Water → HCID 67402674, compound

Participants

Reaction Steps

1-(1,2-Dihydroxyethyl)-4-(trifluoromethyl)benzene (81.0 mg, 0.393 mmol) and triethylamine (57.6 μL, 0.413 mmol) were dissolved in N,N-dimethylformamide (1.6 mL). To this, triisopropylsilyl chloride (87.2 μL, 0.413 mmol) was added under a nitrogen atmosphere at 0° C. and the mixture was stirred at room temperature for 2 hours. After water was added to the reaction mixture, extraction with ethyl acetate was performed, followed by washing with brine and drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=9/1) to give 1-(1-hydroxy-2-triisopropylsiloxyethyl)-4-(trifluoromethyl)benzene (Compound CM) (117 mg, yield: 82%).

Provenance & Evidence