Sodium borohydride → HCID 67403141, compound

Participants

Reaction Steps

3-[Dimethyl(methanesulfonyl)acetyl]pyridine (81.0 mg, 0.356 mmol) was dissolved in methanol (2.0 mL). To this, sodium borohydride (20.2 mg, 0.535 mmol) was added under a nitrogen atmosphere at 0° C. and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated, water was added thereto, and extraction with ethyl acetate was performed, followed by drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by preparative thin-layer chromatography (chloroform/methanol 9/1) to give 3-(2-methanesulfonyl-2-methyl-1-hydroxypropyl)pyridine (Compound CY) (86.7 mg, yield: quantitative).

Provenance & Evidence