Potassium Carbonate → 2,2,2-trifluoro-1-(1-methyl-1H-imidazol-2-yl)ethan-1-ol

Participants

Reaction Steps

According to Reference Example 8-2, by use of 1-methyl-2-imidazolecarboxaldehyde (100 mg, 0.908 mmol), potassium carbonate (25.1 mg, 0.182 mmol), (trifluoromethyl)trimethylsilane (201 μL, 1.36 mmol) and N,N-dimethylformamide (2.0 mL), the mixture was stirred and reacted at room temperature for 2 hours. Then, slurry purification was performed using diisopropyl ether, to give 1-methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)imidazole (Compound DI) (142 mg, yield: 87%).

Provenance & Evidence