Potassium Carbonate → HCID 67402517, compound

Participants

Reaction Steps

According to Reference Example 8-2, by use of 1-methyl-1H-indole-2-carbaldehyde (300 mg, 1.88 mmol) dissolved in N,N-dimethylformamide (4.5 mL), potassium carbonate (52 mg, 0.38 mmol) and (trifluoromethyl)trimethylsilane (0.416 mL, 2.82 mmol), the mixture was stirred and reacted at room temperature for 4 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=100/1) was performed to give 2,2,2-trifluoro-1-(1-methyl-1H-indol-2-yl)ethanol (Compound DQ) (339 mg, yield: 79%).

Provenance & Evidence