Potassium Carbonate → 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol

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Reaction Steps

According to Reference Example 8-2, by use of 2-morpholinothiazole-5-carbaldehyde (177 mg, 0.893 mmol) dissolved in N,N-dimethylformamide (5.3 mL), potassium carbonate (25 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.198 mL, 1.34 mmol), the mixture was stirred and reacted at room temperature for 2.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(2-morpholinothiazol-5-yl)ethanol (Compound DY) (156 mg, yield: 65%).

Provenance & Evidence