Sodium sulfate decahydrate → 1226507-57-8

Participants

Reaction Steps

Tetrahydrofuran (10 mL) was added to lithium aluminum hydride (75 mg, 2.0 mmol). To this, a solution prepared by dissolving, in tetrahydrofuran (5 mL), ethyl 2-methyl-2-(pyridin-3-yl)propanoate (200 mg, 1.0 mmol) obtained in Step 1 of Reference Example 8-63 was slowly added with cooling in an ice bath, and the mixture was stirred at the same temperature for 1 hour. To this, sodium sulfate decahydrate was added and the mixture was stirred at room temperature for 1 hour. After Celite-filtration, the solvent in the filtrate was evaporated off under reduced pressure. Thus, 2-methyl-2-(pyridin-3-yl)propan-1-ol (Compound EK) (154 mg, yield: 99%) was obtained.

Provenance & Evidence