反应详情

3-Pyridinepropanol (300 mg, 2.2 mmol) was dissolved in dichloromethane (5 mL). To this, the Dess-Martin reagent (1.0 g) was added with cooling in an ice bath and the mixture was stirred at the same temperature for 2 hours and successively at room temperature for 3 hours. The solvent in the reaction mixture was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=1/0 to 10/1) to give 3-(pyridin-3-yl)propanal (180 mg, yield: 61%).

1. temperaturewith cooling in an ice bath
2. customThe solvent in the reaction mixture was evaporated off under reduced pressure
3. customthe residue was purified by silica gel column chromatography (chloroform/methanol=1/0 to 10/1)