(Trifluoromethyl)trimethylsilane → HCID 67403989, compound

Participants

Reaction Steps

According to Reference Example 8-12, by use of 3-(pyridin-3-yl)propanal (180 mg, 1.3 mmol) obtained in Step 1 of Reference Example 8-64, (trifluoromethyl)trimethylsilane (0.24 mL, 1.6 mmol), tetrabutylammonium fluoride (a 1.0 mol/L solution in tetrahydrofuran, 0.27 mL, 0.27 mmol) and tetrahydrofuran (3.6 mL), the mixture was stirred and reacted at room temperature for 30 minutes. Then, purification by silica gel column chromatography (chloroform/methanol=1/0 to 10/1) was performed to give 1,1,1-trifluoro-4-(pyridin-3-yl)butan-2-ol (Compound EL) (83 mg, yield: 31%).

Provenance & Evidence