HCID 54400359, compound → Ethyl 3-(pyridin-3-yl)butanoate

HRID 1186396Notes

Reaction equation

HRID 1186396 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([CH3:14])=[CH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:2]=1>[C].[Pd].C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:2]=1

Participants

4

Reactant 1

HCID 54400359HCID 54400359, compound

Product 1

HCID 12727116Ethyl 3-(pyridin-3-yl)butanoateYield 97.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

According to Step 2 of Reference Example 8-65, by use of ethyl 3-(pyridin-3-yl)-2-butenoate (350 mg, 1.8 mmol) obtained in Step 1 of Reference Example 8-66, ethanol (4 mL) and 10% palladium carbon (70 mg), the mixture was stirred and reacted under a hydrogen atmosphere at room temperature for 2 hours. Thus, ethyl 3-(pyridin-3-yl)butanoate (339 mg, yield: 96%) was obtained.

Workup

  1. customreacted under a hydrogen atmosphere at room temperature for 2 hours

Sources & evidence

ORD record
ord-733668631d9a4b09a301edeb40ae4062
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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