Methyl iodide → HCID 67400684, compound

HRID 1186413Notes

Reaction equation

HRID 1186413 reaction equation
[CH2:1]([O:3][CH:4]([O:11][CH2:12][CH3:13])[C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:2].[I:14][CH3:15]>ClCCl>[I-:14].[CH2:12]([O:11][CH:4]([O:3][CH2:1][CH3:2])[C:5]1[CH:6]=[CH:7][N+:8]([CH3:15])=[CH:9][CH:10]=1)[CH3:13]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 153891924-(Diethoxymethyl)pyridine

Product 1

HCID 67400684HCID 67400684, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(Diethoxymethyl)pyridine (4.41 g, 24.3 mmol) was dissolved in dichloromethane (90.0 mL). To this, iodomethane (1.82 mL, 29.2 mmol) was added under a nitrogen atmosphere at room temperature and the mixture was stirred at room temperature for 48 hours. The reaction mixture was concentrated, the residue was washed with diisopropyl ether, and thereby 4-(diethoxymethyl)-1-methylpyridinium iodide (7.47 g, yield: 95%) was obtained.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diisopropyl ether

Sources & evidence

ORD record
ord-97dc4eb04ede4522b7e8c3c65ac7736f
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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