Sodium ethoxide → HCID 67402847, compound

Participants

Reaction Steps

(S)-2,2,2-Trifluoro-1-(6-methylpyridin-3-yl)ethyl(R)-1-phenylethylcarbamate (946 mg, 2.80 mmol) was dissolved in ethanol (14 mL). To this, sodium ethoxide (1.90 g, 28.0 mmol) was added and the mixture was heated to reflux for 2 hours. The reaction mixture was concentrated, a 5% aqueous acetic acid solution was added thereto, and extraction with ethyl acetate was performed, followed by washing with a saturated aqueous sodium bicarbonate solution and brine and drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/7) to give Compound EAA (493 mg, yield: 92%).

Provenance & Evidence