HCID 67401817, compound → HCID 67402546, compound

Participants

Reaction Steps

Ten percent palladium/carbon (170 mg) was suspended in ethanol (5.0 mL). To this, an ethanol solution (25 mL) of 1-benzyloxycarbonyl-4-[2,2,2-trifluoro-1-(triethylsiloxy)-ethyl]piperidine (1.69 g, 3.92 mmol) was added and the mixture was stirred under a hydrogen atmosphere at room temperature for 2.5 hours. The reaction mixture was filtered through Celite and the solvent was evaporated off under reduced pressure. The residue was purified by silica gel column chromatography (chloroform) to give 4-[2,2,2-trifluoro-1-(triethylsiloxy)ethyl]piperidine (1.15 g, yield: 99%).

Provenance & Evidence