Hydrochloric Acid → HCID 67402269, compound

Participants

Reaction Steps

1-Methanesulfonyl-4-[2,2,2-trifluoro-1-(triethyl-siloxy)ethyl]piperidine (300 mg, 0.999 mmol) was dissolved in tetrahydrofuran (2.4 mL). To this, a 1 mol/L aqueous hydrogen chloride solution (2.4 mL) was added and the mixture was stirred at room temperature for 2 hours. The reaction was stopped by addition of a saturated aqueous sodium bicarbonate solution to the reaction mixture, and extraction with ethyl acetate was performed, followed by washing with brine and drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give Compound EAG (198 mg, yield: 95%).

Provenance & Evidence