HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyridine → Pyridine sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Pyridine sulfonamide | HCID 12000791 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Ammonia | HCID 222 | — |
| Product | Pyridine sulfonamide | HCID 12000791 | 15% |
Reaction Steps
According to Reference Example 9-8, by use of 2-bromopyridine (500 mg, 3.2 mmol), diethyl ether (5 mL), n-butyllithium (a 1.56 mol/L solution in hexane, 2.5 mL, 3.8 mmol), sulfuryl chloride (0.28 mL, 3.5 mmol) and a 7 mol/L solution of ammonia in methanol (2 mL), pyridine-2-sulfonamide (Compound FI) (77 mg, yield: 15%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673908B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-fc8ae1c0e7fc4baea94560276d2966ad |
| Source note | uspto-grants-2014_03 |