Ammonia → 2,4-Dimethylthiazole-5-sulfonamide

HRID 1186437Notes

Reaction equation

HRID 1186437 reaction equation
[CH3:1][C:2]1[S:3][C:4]([S:8](Cl)(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1.[NH3:12]>CO>[CH3:1][C:2]1[S:3][C:4]([S:8]([NH2:12])(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 2776248Dimethyl-1,3-thiazole-5-sulfonyl chloride

Product 1

HCID 128731882,4-Dimethylthiazole-5-sulfonamideYield 34%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to Reference Example 9-7, by use of 2,4-dimethylthiazole-5-sulfonyl chloride (250 mg, 1.1 mmol) and a 7 mol/L solution of ammonia in methanol (2 mL), the mixture was stirred and reacted at room temperature for 2 hours. Then, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1) was performed to give 2,4-dimethylthiazole-5-sulfonamide (Compound FL) (60 mg, yield: 34%).

Workup

  1. customreacted at room temperature for 2 hours
  2. customThen, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1)

Sources & evidence

ORD record
ord-13b3e91a772c45de955e504fea7db96c
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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