Ammonia → Cyclohexanesulfonamide

HRID 1186439ノート

反応式

HRID 1186439 の反応式
[CH:1]1([S:7](Cl)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:11]>>[CH:1]1([S:7]([NH2:11])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 222AmmoniaHCID 237554Cyclohexanesulfonyl chloride

生成物 1

HCID 75536Cyclohexanesulfonamide収率 60%

実験手順

According to Reference Example 9-19, by use of cyclohexanesulfonyl chloride (300 mg, 1.6 mmol) and a 25% aqueous ammonia solution (2 mL), the mixture was stirred and reacted at room temperature for 18 hours. Then, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1) was performed to give cyclohexanesulfonamide (Compound FW) (161 mg, yield: 60%).

後処理

  1. customreacted at room temperature for 18 hours
  2. customThen, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1)

出典と根拠

ORDレコード
ord-2b9a908a56cf4d7cbeeded1199c1c223
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

反応ノート

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